Produced by Chris Brown Sean Furst Bryan Furst
Written by Peter Spierig Michael Spierig
Starring Ethan Hawke Willem Dafoe Claudia Karvan
Michael Dorman Sam Neill Vince Colosimo Isabel Lucas
In 2019, a plague has transformed 90% of the world's human population into vampires. As the vampires are incapable of aging or dying, but they are unprotected against the UV lights or the sunlight, which is why the whole vampire world is active at night. Human numbers dwindle and the need for blood becomes desperate while an all-out war rages around the world between the surviving humans and vampires despite their efforts. When deprived of blood for extended periods, vampires degenerate into subsiders: aggressive bat-like creatures. Humans are captured and harvested in laboratory farms while scientists research a synthetic blood substitute to satisfy vampires' blood hunger. The main supplier of blood in the United States is the pharmaceutical company Bromley Marks, run by Charles Bromley (Sam Neill). Edward Dalton (Ethan Hawke) and Chris Caruso (Vince Colosimo) are hematologists working on the blood substitute. Under pressure from Charles, they try multiple versions in a series of failing clinical trials. Edward secretly refuses to drink human blood, and faces a strained relationship with his brother, Frankie (Michael Dorman), a human-hunting soldier.
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